Dear Health Care Provider,
African Services Committee has provided health, social and legal
services to HIV+ African immigrants and refugees throughout the New York metropolitan area
for over 19 years. We write this letter regarding a health issue facing many of your HIV+
African, Asian and Latin American patients.
In the past few years, researchers and doctors have uncovered the
global prevalence of HIV genetic variation. Virtually all of the diagnostic tools and
antiretroviral treatment for HIV have been based on HIV-1 B, the strain of HIV prevalent
throughout North America and Western Europe. However, the ten HIV-1 non-B subtypes and
HIV-2, not HIV-1 B, comprise the absolute majority of infections worldwide, and especially
throughout Africa, Asia and Latin America.
Over 90% of our African HIV+ clients in New York City who have
tested for their HIV type/subtype have been diagnosed with a variant of HIV other
than HIV-1 B.
African Services Committee runs the HIV Variant Project with the
assistance of the New York City Department of Health (NYC DOH) Bureau of Labs. We work to
ensure the best possible care for HIV+ immigrants through HIV type/subtype testing and
function as a resource for health care providers, with information about appropriate viral
load monitoring, resistance testing and antiretroviral treatment as they apply to HIV
genetic variance. The HIV Variant Project is funded by the Congressional Black Caucus
through a Ryan White Title I Enhancement of Services Grant.
Because of the relatively recent discovery of HIV-1 non-B subtypes
and HIV-2, medical management of these types/subtypes has yet to be incorporated into HIV
standards of care. Therefore, we recommend the following:
- HIV+ African, Asian and Latin American patients should undergo an HIV
type/subtype test, performed free of charge through African Services Committee and Aaron
Diamond AIDS Research Center.
- If a patient is diagnosed with an HIV-1 non-B subtype, request the
Bayer bDNA viral load test or Organon Teknika NASBA viral load test. These viral load
tests accurately quantify HIV-1 non-B viral loads. The standard viral load assay, Roche
RT-PCR, does not accurately quantify HIV-1 non-B subtypes. Using the Roche RT-PCR may
result in an incongruous lab result (i.e. low CD4 count and low viral load level). HIV-2
viral load cannot be quantified by any of the commercially available assays, and will thus
(falsely) report as undetectable.
- To arrange an HIV type/subtype test or to learn about where you can
get the appropriate viral load tests for free, please contact African Services Committee
and ask for Neil Sachs or Rusha Pearson.
If you would like more information about the HIV Variant Project,
HIV
type/subtype testing and appropriate viral load monitoring, please contact us.
Kind regards,
Martha Kahirimbanyi
Program Coordinator
212.222.3882 x 125
Erika Brutsaert
Program Educator
212.222.3882 x 120 |
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